Busuttil A, More I A, McSeveney D
Arch Otolaryngol. 1976 Oct;102(10):589-95. doi: 10.1001/archotol.1976.00780150057002.
Ultrastructural examination of the stroma of simple nasal polyps was shown that there is an edematous framework of fibroblasts with abundant interdigitating cytoplasmic processes, a plexus of inflamed blood vessels, and a mixed infiltrate of active inflammatory cells. Solitary cilia were seen to arise from the stromal mesenchymal cells; no mycoplasma or viral inclusions were present. These features may have a relationship to the pathogenesis of nasal polyps. An immunologically induced liberation of vasoactive amines from mast cells results in increased capillary permeability and a consequent excess of intracellular fluid; the stromal cells attempt to check this expansion by an increase in collagen synthesis.
对单纯鼻息肉基质的超微结构检查显示，存在一个由成纤维细胞构成的水肿性框架，其细胞质突起相互交错丰富，有炎症性血管丛，以及活跃炎症细胞的混合浸润。可见孤立的纤毛从基质间充质细胞长出；未发现支原体或病毒包涵体。这些特征可能与鼻息肉的发病机制有关。免疫诱导肥大细胞释放血管活性胺导致毛细血管通透性增加，进而细胞内液过多；基质细胞试图通过增加胶原蛋白合成来抑制这种扩张。
