Naito M, Tsuruo T
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Methods Enzymol. 1998;292:258-65. doi: 10.1016/s0076-6879(98)92020-1.
P-Glycoprotein, a member of the ABC transporter group, plays an important role in anticancer drug resistance. Many monoclonal antibodies to P-glycoprotein have been developed and used to study the molecular and cellular functions of P-glycoprotein. These monoclonal antibodies were used for gene cloning, purification and reconstitution of P-glycoprotein, analysis of transport functions of P-glycoprotein, immunological detection and selective killing of tumors that express P-glycoprotein for diagnostic, and therapeutic purposes.
P-糖蛋白是ABC转运蛋白家族的成员之一，在抗癌药物耐药性中发挥着重要作用。许多针对P-糖蛋白的单克隆抗体已被开发出来，并用于研究P-糖蛋白的分子和细胞功能。这些单克隆抗体被用于P-糖蛋白的基因克隆、纯化和重组、P-糖蛋白转运功能的分析、免疫检测以及对表达P-糖蛋白的肿瘤进行选择性杀伤，以用于诊断和治疗目的。
