Plouffe L, Simon J A
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, USA.
Semin Reprod Endocrinol. 1998;16(2):135-43. doi: 10.1055/s-2007-1016264.
Interest in the effects of androgens on the central nervous system (CNS) in postmenopausal women dates back to at least fifty years. The mechanisms of action of androgens on the CNS are extremely complex and multi-faceted. Much data has been accumulated in recent years that suggest a beneficial role of androgens in several aspects of CNS function. These include positive effects on mood, cognition, memory, and libido. The information continues to be preliminary in nature and requires further investigations. There is evidence of altered androgen metabolism triggered by exogenous postmenopausal estrogen therapy. While promising, the current body of evidence does not yet support the routine addition of androgens to postmenopausal hormone therapy.
对雄激素对绝经后女性中枢神经系统（CNS）影响的关注至少可以追溯到五十年前。雄激素对中枢神经系统的作用机制极其复杂且多方面。近年来积累了大量数据，表明雄激素在中枢神经系统功能的多个方面具有有益作用。这些包括对情绪、认知、记忆和性欲的积极影响。这些信息本质上仍然是初步的，需要进一步研究。有证据表明外源性绝经后雌激素治疗会引发雄激素代谢改变。虽然前景乐观，但目前的证据尚不支持在绝经后激素治疗中常规添加雄激素。
