Bullard D E, Nashold B S
Raleigh Neurosurgical Clinic, N.C., USA.
Stereotact Funct Neurosurg. 1997;68(1-4 Pt 1):168-74. doi: 10.1159/000099918.
During a 3-year period, 25 caudalis dorsal root entry zone (DREZ) operations were done for severe, facial pain. Intraoperative brainstem recordings were done before and after DREZ in all patients. Primary diagnosis included refractory trigeminal neuralgia, atypical headaches or facial pain, posttraumatic closed head injuries, postsurgical anesthesia dolorosa, multiple sclerosis, brainstem infarction, postherpetic neuralgia and cancer-related pain. At the time of discharge, good to excellent pain relief was present in 24/25 patients and fair relief in 1. At 1 month, 19/25 (76%) patients had good to excellent results and at 3 months following surgery, 17/25 (68%) continued to have good to excellent pain relief. One year following surgery, 18 patients could be evaluated, 12/18 (67%) still considered their relief as good to excellent, 2 fair and 4 poor. Transient postoperative ataxia was present in 15/25 patients (60%), but was largely resolved at 1 months. In 3/18 (17%) patients, a degree of ataxia was still present at 1 year although in none was it disabling. Two patients had transient diplopia, and 3 had increased corneal anesthesia with 1 later developing a keratitis. No surgical or postsurgical mortality was noted. This procedure has proven to be a satisfactory treatment for many patients with debilitating facial pain syndromes with acceptable morbidity.
在3年期间,对25例严重面部疼痛患者进行了尾侧背根入髓区(DREZ)手术。所有患者在DREZ手术前后均进行了术中脑干记录。主要诊断包括难治性三叉神经痛、非典型头痛或面部疼痛、创伤后闭合性颅脑损伤、术后麻醉性疼痛、多发性硬化症、脑干梗死、带状疱疹后神经痛和癌症相关疼痛。出院时,25例患者中有24例疼痛缓解良好至极佳,1例缓解一般。1个月时,25例患者中有19例(76%)结果良好至极佳;术后3个月,25例患者中有17例(68%)仍有良好至极佳的疼痛缓解。术后1年,18例患者可进行评估,18例中有12例(67%)仍认为疼痛缓解良好至极佳,2例一般,4例较差。15/25例患者(60%)出现短暂性术后共济失调,但在1个月时基本缓解。18例患者中有3例(17%)在1年时仍有一定程度的共济失调,但均未导致残疾。2例患者出现短暂性复视,3例角膜感觉减退加重,其中1例后来发生角膜炎。未观察到手术或术后死亡。对于许多患有使人衰弱的面部疼痛综合征的患者来说,该手术已被证明是一种令人满意的治疗方法,其发病率可以接受。