Sakai T, Matsuura B, Onji M
Third Department of Internal Medicine, Ehime University School of Medicine.
Intern Med. 1998 Jul;37(7):581-4. doi: 10.2169/internalmedicine.37.581.
We investigated the serum paraoxonase (PON) activity and genotype distribution in 139 patients with non-insulin-dependent diabetes mellitus and in 240 control subjects in a Japanese population. There were no significant differences in PON genotype frequencies between the diabetic and control subjects, but the PON activity was significantly less in diabetic subjects (p<0.01). PON activity was significantly related to levels of total cholesterol and high density lipoprotein (HDL) cholesterol in the control subjects, but not in the diabetic subjects. In diabetic subjects with the genotype AA, the mean maximum intimal-medial thickness (IMT) of the carotid artery was significantly greater than in subjects with genotype AB or BB. PON may play an important role in the development of atherosclerosis associated with diabetes mellitus.
我们对139例非胰岛素依赖型糖尿病患者及240名日本对照者的血清对氧磷酶（PON）活性及基因型分布进行了研究。糖尿病患者与对照者之间的PON基因型频率无显著差异，但糖尿病患者的PON活性显著较低（p<0.01）。在对照者中，PON活性与总胆固醇及高密度脂蛋白（HDL）胆固醇水平显著相关，但在糖尿病患者中则不然。在基因型为AA的糖尿病患者中，颈动脉平均最大内膜中层厚度（IMT）显著大于基因型为AB或BB的患者。PON可能在糖尿病相关动脉粥样硬化的发生发展中起重要作用。
