Takeda S, Kida H, Yokoyama H, Takazakura E, Kobayashi K
Internal Medicine of Kurobe City Hospital, Toyama.
Intern Med. 1998 Jul;37(7):585-91. doi: 10.2169/internalmedicine.37.585.
To clarify the effectiveness of methylprednisolone pulse therapy on crescentic glomerulonephritis (CresGN), data of 46 patients was retrospectively studied. According to the slope of reciprocals of serum creatinine (s-Cr) the patients were divided into acute and insidious types, and each type was further divided into pulse (P) and conventional (C) therapy groups. In group C, s-Cr improved more frequently in the acute type (8/10) than in the insidious type (1/9, p<0.05), and the renal survival rate was somewhat higher in the former (p=0.09). In the acute type there was no difference in the improvement rate of s-Cr between the two therapy groups, whereas in the insidious type, the improvement rate was higher in group P (9/15) than in group C (1/9, p<0.05) and the renal survival rate was higher in the former (p<0.01). These results suggest that methylprednisolone pulse therapy may be highly effective for the insidious type of CresGN.
为阐明甲泼尼龙冲击疗法对新月体性肾小球肾炎（CresGN）的疗效，对46例患者的数据进行了回顾性研究。根据血清肌酐（s-Cr）倒数的斜率将患者分为急性型和隐匿型，每种类型再进一步分为冲击治疗（P）组和传统治疗（C）组。在C组中，急性型患者的s-Cr改善情况（8/10）比隐匿型患者（1/9，p<0.05）更常见，且前者的肾脏生存率略高（p=0.09）。在急性型中，两个治疗组之间s-Cr的改善率没有差异，而在隐匿型中，P组的改善率（9/15）高于C组（1/9，p<0.05），且前者的肾脏生存率更高（p<0.01）。这些结果表明，甲泼尼龙冲击疗法可能对隐匿型CresGN非常有效。
