Skyba D M, Price R J, Linka A Z, Skalak T C, Kaul S
Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA.
Circulation. 1998 Jul 28;98(4):290-3. doi: 10.1161/01.cir.98.4.290.
Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and to characterize any resultant bioeffects.
Intravital microscopy was used to visualize the spinotrapezius muscle in 15 rats during ultrasound delivery. Microbubble destruction during ultrasound exposure caused rupture of < or = 7-microm microvessels (mostly capillaries) and the production of nonviable cells in adjacent tissue. The number of microvessels ruptured and cells damaged correlated linearly (P<0.001) with the amount of ultrasound energy delivered.
Microbubbles can be destroyed by ultrasound, resulting in a bioeffect that could be used for local drug delivery, angiogenesis, and vascular remodeling, or for tumor destruction.
我们的目的是在体内观察超声诱导的血管内微泡破坏，并描述由此产生的任何生物效应。
在15只大鼠超声照射期间，采用活体显微镜观察斜方肌。超声暴露期间微泡破坏导致直径小于或等于7微米的微血管（主要是毛细血管）破裂，并在相邻组织中产生无活力细胞。破裂的微血管数量和受损细胞数量与传递的超声能量呈线性相关（P<0.001）。
微泡可被超声破坏，产生一种可用于局部药物递送、血管生成和血管重塑或肿瘤破坏的生物效应。
