Halpern M, Jia C, Shapiro L S
Department of Anatomy and Cell Biology, SUNY Health Science Center at Brooklyn, New York 11203, USA.
Microsc Res Tech. 1998 Jun 15;41(6):519-29. doi: 10.1002/(SICI)1097-0029(19980615)41:6<519::AID-JEMT7>3.0.CO;2-H.
The vomeronasal system of mammals is chemoarchitecturally dichotomous. Two populations of receptor cells have been identified in the vomeronasal sensory epithelium based on the family of receptor proteins they express on their membranes. These two receptor cell populations express different G-proteins: the more basal population expresses Goalpha and the more apical population expresses Gialpha2. The Goalpha-expressing receptor cells project their axons to the posterior accessory olfactory bulb (AOB) whereas the Gialpha2-expressing cells project their axons to the anterior AOB. In all mammals studied to date, the anterior AOB is Gialpha2-positive and the posterior AOB is Goalpha-positive. These two parts of the AOB are also chemoarchitecturally heterogeneous with respect to their carbohydrate content as revealed both with lectin binding and immunoreactivity to monoclonal antibodies raised against carbohydrate moieties. However, species differences have been observed with respect to lectin binding, as with NADPH-diaphorase reactions and OMP immunoreactivity. Recent studies indicate that there are physiological and behavioral correlates to the dichotomy within the vomeronasal system.
哺乳动物的犁鼻系统在化学结构上是二分的。基于它们在细胞膜上表达的受体蛋白家族，在犁鼻感觉上皮中已鉴定出两类受体细胞。这两类受体细胞表达不同的G蛋白：较靠基底的细胞群表达Goα，而较靠顶端的细胞群表达Giα2。表达Goα的受体细胞将其轴突投射到后副嗅球（AOB），而表达Giα2的细胞将其轴突投射到前AOB。在迄今研究的所有哺乳动物中，前AOB是Giα2阳性的，而后AOB是Goα阳性的。正如通过凝集素结合以及针对碳水化合物部分产生的单克隆抗体的免疫反应所揭示的那样，AOB的这两个部分在碳水化合物含量方面在化学结构上也是异质的。然而，在凝集素结合方面已观察到物种差异，在NADPH-黄递酶反应和OMP免疫反应性方面也是如此。最近的研究表明，犁鼻系统内的这种二分法存在生理和行为上的关联。
