Gage F H, Kempermann G, Palmer T D, Peterson D A, Ray J
Laboratory of Genetics, The Salk Institute, La Jolla, CA 92037, USA.
J Neurobiol. 1998 Aug;36(2):249-66. doi: 10.1002/(sici)1097-4695(199808)36:2<249::aid-neu11>3.0.co;2-9.
Neurogenesis persists in the adult dentate gyrus of rodents throughout the life of the organism. The factors regulating proliferation, survival, migration, and differentiation of neuronal progenitors are now being elucidated. Cells from the adult hippocampus can be propagated, cloned in vitro, and induced to differentiate into neurons and glial cells. Cells cultured from the adult rodent hippocampus can be genetically marked and transplanted back to the adult brain, where they survive and differentiate into mature neurons and glial cells. Although multipotent stem cells exist in the adult rodent dentate gyrus, their biological significance remains elusive.
在啮齿动物的成年齿状回中，神经发生在整个生物体的生命过程中持续存在。目前正在阐明调节神经元祖细胞增殖、存活、迁移和分化的因素。成年海马体中的细胞可以在体外进行增殖、克隆，并被诱导分化为神经元和神经胶质细胞。从成年啮齿动物海马体中培养的细胞可以进行基因标记，然后移植回成年大脑，在那里它们存活并分化为成熟的神经元和神经胶质细胞。尽管成年啮齿动物齿状回中存在多能干细胞，但其生物学意义仍然难以捉摸。
