Ferrara J L
Division of Pediatric Oncology, Dana Farber Cancer Institute and Children's Hospital, Boston, MA 02115, USA.
Bone Marrow Transplant. 1998 Jun;21 Suppl 3:S13-5.
Acute graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow transplantation (BMT), significantly limits the application of this important therapy. Advances in basic immunobiology, and particularly in the dissection of the complex networks of cytokines that affect the function of immune cells, have increased our understanding of the effector mechanisms of acute GVHD. Data from both experimental and clinical studies suggest that inflammatory cytokines are critical components of acute GVHD that can be modulated by a number of proteins, including anti-inflammatory cytokines and cytokine antagonists.
急性移植物抗宿主病（GVHD）是同种异体骨髓移植（BMT）的主要并发症，严重限制了这一重要治疗方法的应用。基础免疫生物学的进展，尤其是在剖析影响免疫细胞功能的复杂细胞因子网络方面的进展，增进了我们对急性GVHD效应机制的理解。实验研究和临床研究的数据均表明，炎性细胞因子是急性GVHD的关键组成部分，可被多种蛋白质调节，包括抗炎细胞因子和细胞因子拮抗剂。
