高危白血病患者接受来自人类白细胞抗原不匹配无关供者的脐带血移植。
Umbilical cord blood transplant from HLA-mismatched unrelated donor in high-risk leukemia.
作者信息
Arcese W, Iori A P, Screnci M, Guglielmi C, Mengarelli A, Carmini D, Testi A M, Moleti M L, Cimino G, Perrone P, Laurenti L, Elia L, Boecklin F, Romano A, De Felice L, Mandelli F
机构信息
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy.
出版信息
Bone Marrow Transplant. 1998 Jun;21 Suppl 3:S85-6.
Twelve consecutive children with high-risk leukemia have been submitted to UCB transplant from unrelated 1 or 2 loci HLA-mismatched donor. All patients received an identical regimen for conditioning and GVHD prophylaxis. The median dose of viable nucleated cells infused was 2.8 x 10(7)/kg bw (range 1.4-7.9). Of 11 patients evaluable for engraftment, the hematopoiesis was of full donor origin in seven patients and autologous in four. The probability of disease-free survival at 1 and 2 years from UCB transplant is 60 and 42%, respectively.
12名患有高危白血病的连续儿童接受了来自1或2个位点HLA不匹配的无关供体的脐血移植。所有患者均接受相同的预处理和移植物抗宿主病预防方案。输注的有活力有核细胞的中位剂量为2.8×10(7)/kg体重（范围1.4 - 7.9）。在11名可评估植入情况的患者中，7名患者的造血功能完全来自供体，4名患者为自体造血。脐血移植后1年和2年的无病生存率分别为60%和42%。
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