Evans C A, Garcia H H, Hartnell A, Gilman R H, Jose P J, Martinez M, Remick D G, Williams T J, Friedland J S
Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom.
Infect Immun. 1998 Sep;66(9):4522-5. doi: 10.1128/IAI.66.9.4522-4525.1998.
Symptomatic neurocysticercosis, a major cause of epilepsy worldwide, results from inflammation around Taenia solium larvae, but the mechanisms are unknown. Eotaxin, not previously reported in cases of human infection, and interleukin-5 (IL-5) but not IL-8 concentrations were elevated in patient serum, and IL-5 levels were also elevated in cerebrospinal fluid (CSF). Eosinophil-selective mediators may be involved in the pathogenesis of cysticercosis. IL-6 concentrations were also elevated in patient CSF, possibly indicative of an acute-phase response.
症状性神经囊尾蚴病是全球癫痫的主要病因,由猪带绦虫幼虫周围的炎症引起,但其机制尚不清楚。嗜酸性粒细胞趋化因子在人类感染病例中此前未见报道,患者血清中嗜酸性粒细胞趋化因子和白细胞介素-5(IL-5)浓度升高,而IL-8浓度未升高,脑脊液(CSF)中IL-5水平也升高。嗜酸性粒细胞选择性介质可能参与囊尾蚴病的发病机制。患者脑脊液中IL-6浓度也升高,可能提示急性期反应。