人类神经囊尾蚴病中嗜酸性粒细胞趋化因子和白细胞介素-5浓度升高。
Elevated concentrations of eotaxin and interleukin-5 in human neurocysticercosis.
作者信息
Evans C A, Garcia H H, Hartnell A, Gilman R H, Jose P J, Martinez M, Remick D G, Williams T J, Friedland J S
机构信息
Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom.
出版信息
Infect Immun. 1998 Sep;66(9):4522-5. doi: 10.1128/IAI.66.9.4522-4525.1998.
Abstract
Symptomatic neurocysticercosis, a major cause of epilepsy worldwide, results from inflammation around Taenia solium larvae, but the mechanisms are unknown. Eotaxin, not previously reported in cases of human infection, and interleukin-5 (IL-5) but not IL-8 concentrations were elevated in patient serum, and IL-5 levels were also elevated in cerebrospinal fluid (CSF). Eosinophil-selective mediators may be involved in the pathogenesis of cysticercosis. IL-6 concentrations were also elevated in patient CSF, possibly indicative of an acute-phase response.
摘要
症状性神经囊尾蚴病是全球癫痫的主要病因，由猪带绦虫幼虫周围的炎症引起，但其机制尚不清楚。嗜酸性粒细胞趋化因子在人类感染病例中此前未见报道，患者血清中嗜酸性粒细胞趋化因子和白细胞介素-5（IL-5）浓度升高，而IL-8浓度未升高，脑脊液（CSF）中IL-5水平也升高。嗜酸性粒细胞选择性介质可能参与囊尾蚴病的发病机制。患者脑脊液中IL-6浓度也升高，可能提示急性期反应。
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本文引用的文献
1
Granuloma cytokines in murine cysticercosis.小鼠囊尾蚴病中的肉芽肿细胞因子
Infect Immun. 1997 Jul;65(7):2925-31. doi: 10.1128/iai.65.7.2925-2931.1997.
2
Neurocysticercosis: a major cause of neurological disease worldwide.神经囊尾蚴病：全球神经系统疾病的主要病因。
Clin Infect Dis. 1997 Feb;24(2):101-13; quiz 114-5. doi: 10.1093/clinids/24.2.101.
3
Proposal of diagnostic criteria for human cysticercosis and neurocysticercosis.
J Neurol Sci. 1996 Oct;142(1-2):1-6. doi: 10.1016/0022-510x(96)00130-x.
4
Mice infected with the larvae of Taenia crassiceps exhibit a Th2-like immune response with concomitant anergy and downregulation of Th1-associated phenomena.感染肥胖带绦虫幼虫的小鼠表现出类似Th2的免疫反应，同时伴有无反应性和Th1相关现象的下调。
Parasitology. 1996 Jun;112 ( Pt 6):561-70. doi: 10.1017/s0031182000066142.
5
Chemokines active on eosinophils: potential roles in allergic inflammation.对嗜酸性粒细胞有活性的趋化因子：在变应性炎症中的潜在作用
J Exp Med. 1996 Jun 1;183(6):2421-6. doi: 10.1084/jem.183.6.2421.
6
Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.人嗜酸性粒细胞趋化因子（一种嗜酸性粒细胞选择性CC趋化因子）的分子克隆以及特异性嗜酸性粒细胞趋化因子受体CC趋化因子受体3的鉴定。
J Biol Chem. 1996 Mar 29;271(13):7725-30. doi: 10.1074/jbc.271.13.7725.
7
Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.人嗜酸性粒细胞趋化因子（eotaxin）的克隆。其表达、受体结合及功能特性提示了嗜酸性粒细胞选择性募集的一种机制。
J Clin Invest. 1996 Feb 1;97(3):604-12. doi: 10.1172/JCI118456.
8
Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse.用抗IL-5抗体清除嗜酸性粒细胞可提高广州管圆线虫颅内寄生虫在小鼠体内的存活率。
Parasite Immunol. 1993 Jun;15(6):349-54. doi: 10.1111/j.1365-3024.1993.tb00619.x.
9
Neurocysticercosis in Houston, Texas. A report of 112 cases.德克萨斯州休斯顿的神经囊尾蚴病。112例报告。
Medicine (Baltimore). 1994 Jan;73(1):37-52. doi: 10.1097/00005792-199401000-00004.
10
Tumor necrosis factor plays a role in Schistosoma mansoni egg-induced granulomatous inflammation.肿瘤坏死因子在曼氏血吸虫卵诱导的肉芽肿性炎症中起作用。
J Immunol. 1993 Nov 15;151(10):5461-71.
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