Garcia H H, Rodriguez S, Friedland J S
Department of Microbiology, School of Sciences and Center for Global Health - Tumbes, Universidad Peruana Cayetano Heredia, Lima, Peru; Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Parasite Immunol. 2014 Aug;36(8):388-96. doi: 10.1111/pim.12126.
The life cycle of Taenia solium, the pork tapeworm, is continuously closed in many rural settings in developing countries when free roaming pigs ingest human stools containing T. solium eggs and develop cysticercosis, and humans ingest pork infected with cystic larvae and develop intestinal taeniasis, or may also accidentally acquire cysticercosis by faecal-oral contamination. Cysticercosis of the human nervous system, neurocysticercosis, is a major cause of seizures and other neurological morbidity in most of the world. The dynamics of exposure, infection and disease as well as the location of parasites result in a complex interaction which involves immune evasion mechanisms and involutive or progressive disease along time. Moreover, existing data are limited by the relative lack of animal models. This manuscript revises the available information on the immunology of human taeniasis and cysticercosis.
猪带绦虫的生命周期在发展中国家的许多农村地区不断循环,当自由放养的猪摄入含有猪带绦虫卵的人类粪便并患上囊尾蚴病时,人类摄入感染囊尾幼虫的猪肉并患上肠绦虫病,或者也可能因粪口污染而意外感染囊尾蚴病。人类神经系统的囊尾蚴病,即神经囊尾蚴病,是世界上大多数地区癫痫发作和其他神经疾病的主要原因。暴露、感染和疾病的动态变化以及寄生虫的位置导致了一种复杂的相互作用,其中涉及免疫逃避机制以及随着时间推移的退化性或进行性疾病。此外,现有数据因相对缺乏动物模型而受到限制。本手稿修订了关于人类绦虫病和囊尾蚴病免疫学的现有信息。