感染硕大利什曼原虫的小鼠中，白细胞介素-2合成能力的增强与疾病进展平行。
Increased capacity for interleukin-2 synthesis parallels disease progression in mice infected with Leishmania major.
作者信息
Heinzel F P, Rerko R M, Hujer A M, Maier R A
机构信息
Division of Geographic Medicine, Case Western Reserve University School of Medicine, and the VA Medical Center, Cleveland, Ohio 44106, USA.
出版信息
Infect Immun. 1998 Sep;66(9):4537-40. doi: 10.1128/IAI.66.9.4537-4540.1998.
Abstract
Lymph node cells of BALB/c mice with progressive leishmaniasis produced sixfold more interleukin-2 (IL-2) in culture than those of healing C57BL/6 mice. IL-2 synthesis also increased in C57BL/6 mice made susceptible by IL-12 or gamma interferon deficiency. However, IL-2 mRNA levels in vivo did not reflect IL-2 production in vitro. Because IL-2 contributes to the pathogenesis of progressive leishmaniasis, the functional significance of these findings should be further explored.
摘要
患有进行性利什曼病的BALB/c小鼠的淋巴结细胞在培养物中产生的白细胞介素-2（IL-2）比正在康复的C57BL/6小鼠的淋巴结细胞多五倍。在因IL-12或γ干扰素缺乏而变得易感的C57BL/6小鼠中，IL-2的合成也增加了。然而，体内IL-2 mRNA水平并未反映体外IL-2的产生情况。由于IL-2促成了进行性利什曼病的发病机制，这些发现的功能意义应进一步探究。
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本文引用的文献
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