Increased capacity for interleukin-2 synthesis parallels disease progression in mice infected with Leishmania major.
作者信息
Heinzel F P, Rerko R M, Hujer A M, Maier R A
机构信息
Division of Geographic Medicine, Case Western Reserve University School of Medicine, and the VA Medical Center, Cleveland, Ohio 44106, USA.
出版信息
Infect Immun. 1998 Sep;66(9):4537-40. doi: 10.1128/IAI.66.9.4537-4540.1998.
Abstract
Lymph node cells of BALB/c mice with progressive leishmaniasis produced sixfold more interleukin-2 (IL-2) in culture than those of healing C57BL/6 mice. IL-2 synthesis also increased in C57BL/6 mice made susceptible by IL-12 or gamma interferon deficiency. However, IL-2 mRNA levels in vivo did not reflect IL-2 production in vitro. Because IL-2 contributes to the pathogenesis of progressive leishmaniasis, the functional significance of these findings should be further explored.
摘要
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本文引用的文献
1
Early IL-4 production does not predict susceptibility to Leishmania major.
Exp Parasitol. 1996 Nov;84(2):178-87. doi: 10.1006/expr.1996.0103.
2
Soluble cytokine receptors: their roles in immunoregulation, disease, and therapy.
Adv Immunol. 1996;63:269-336. doi: 10.1016/s0065-2776(08)60858-5.
3
Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor.
J Immunol. 1996 Sep 1;157(5):1846-53.
4
IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.
J Immunol. 1993 May 1;150(9):3924-31.
5
Production of soluble IL-4 receptors by murine spleen cells is regulated by T cell activation and IL-4.
J Immunol. 1993 Dec 1;151(11):5907-17.
6
Interleukin-1 and interferon-alpha augment interleukin-2 (IL-2) production by distinct mechanisms at the IL-2 mRNA level.
Cell Immunol. 1994 Sep;157(2):549-55. doi: 10.1006/cimm.1994.1249.
7
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.
J Exp Med. 1994 Apr 1;179(4):1367-71. doi: 10.1084/jem.179.4.1367.
8
The regulation of immunity to Leishmania major.
Annu Rev Immunol. 1995;13:151-77. doi: 10.1146/annurev.iy.13.040195.001055.
9
Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.
J Immunol. 1995 Jul 15;155(2):730-9.
10
Internalization of interleukin 2 (IL-2) by high affinity IL-2 receptors is required for the growth of IL-2-dependent T cell lines.
J Immunol. 1987 Dec 1;139(11):3680-4.
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