Johnson J R
University of Minnesota and Minneapolis VA Medical Center, Minneapolis, Minnesota, USA.
Infect Immun. 1998 Sep;66(9):4568-71. doi: 10.1128/IAI.66.9.4568-4571.1998.
Alleles I, II, and III of the P adhesin gene papG were sought by PCR among 75 Escherichia coli blood isolates from adults with urosepsis, and the papG genotype was compared with associated bacterial characteristics and host compromise status. Allele II predominated over allele III in the total population (71% of the strains versus 7% for allele III; P < 0.01). Allele I was not encountered. In comparison with allele II, allele III was significantly associated with the presence of hly and the absence of iuc (which encode hemolysin and aerobactin biosynthesis), nonagglutination of digalactoside-coated beads, absence of aerobactin production, membership in serogroups O6 and O18, and host compromise, particularly cancer and upper urinary tract abnormalities.
通过聚合酶链反应（PCR）在75株来自患有泌尿道感染败血症的成人的大肠杆菌血液分离株中寻找P菌毛粘附素基因papG的等位基因I、II和III，并将papG基因型与相关细菌特征和宿主受损状况进行比较。在总体人群中，等位基因II比等位基因III更占优势（71%的菌株为等位基因II，而等位基因III为7%；P<0.01）。未发现等位基因I。与等位基因II相比，等位基因III与hly的存在、iuc的缺失（分别编码溶血素和气杆菌素生物合成）、二半乳糖苷包被珠的不凝集、气杆菌素产生的缺失、血清群O6和O18的成员身份以及宿主受损，特别是癌症和上尿路异常显著相关。
