Chee H L, Pua H L, Tan S
Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital.
Singapore Med J. 1998 May;39(5):200-1.
The aim of this study was to evaluate the clinical use of mivacurium, a short-acting, non-depolarising muscle relaxant, in the paediatric population in Singapore.
Twenty children between the ages of 2 and 12 years were given mivacurium to maintain neuromuscular blockade during nitrous oxide-halothane anaesthesia. Reversal from neuromuscular blockade was spontaneous. The onset, ease of intubation after different doses of mivacurium, and the ease of reversal were evaluated.
Different intubating doses of mivacurium did not result in significantly different times of onset. The mean recovery index (25% to 75% recovery) was 4.1 minutes. There were no adverse reactions.
Mivacurium provided rapid and efficacious onset of neuromuscular blockade in the local paediatric population. Rapid spontaneous recovery obviated the need for reversal agents.
本研究旨在评估短效非去极化肌松药米库氯铵在新加坡儿科人群中的临床应用。
20名年龄在2至12岁的儿童在氧化亚氮-氟烷麻醉期间给予米库氯铵以维持神经肌肉阻滞。神经肌肉阻滞的恢复是自发的。评估了不同剂量米库氯铵后的起效时间、插管难易程度以及恢复的难易程度。
不同插管剂量的米库氯铵起效时间无显著差异。平均恢复指数（25%至75%恢复）为4.1分钟。未出现不良反应。
米库氯铵在当地儿科人群中能快速有效地产生神经肌肉阻滞。快速的自发恢复消除了使用逆转剂的必要性。
