烯丙胺型呫吨酮抗真菌药。

Allylamine type xanthone antimycotics.

作者信息

Salmoiraghi I, Rossi M, Valenti P, Da Re P

机构信息

Institute of Pharmaceutical Chemistry, University of Milan, Italy.

出版信息

Arch Pharm (Weinheim). 1998 Jun;331(6):225-7. doi: 10.1002/(sici)1521-4184(199806)331:6<225::aid-ardp225>3.0.co;2-5.

DOI:10.1002/(sici)1521-4184(199806)331:6<225::aid-ardp225>3.0.co;2-5

PMID:9713256

Abstract

A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions are described. The in vitro antifungal activity against representative strains of molds and yeasts is reported. Only butenafine xanthone analogues show significant activity against Cryptococcus neoformans, in particular the regioisomer 4d (1.5 micrograms/ml).

摘要

描述了一系列在1、2、3和4核位置带有萘替芬和布替萘芬抗真菌药基本链的呫吨酮衍生物。报道了其对代表性霉菌和酵母菌株的体外抗真菌活性。只有布替萘芬呫吨酮类似物对新型隐球菌显示出显著活性，特别是区域异构体4d（1.5微克/毫升）。