Lane A H, Donahoe P K
Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston 02114, USA.
J Endocrinol. 1998 Jul;158(1):1-6. doi: 10.1677/joe.0.1580001.
The primary function of MIS in mammals is to initiate regression of Mullerian structures in males as part of normal sexual development. As we learn more about its other roles, particularly its influence on the growth and differentiation of cell types within the gonad, a more thorough understanding of the receptors that MIS stimulates and the downstream signaling cascade with which it interacts will help in the development of diagnostic and therapeutic uses of MIS.
在哺乳动物中，缪勒管抑制物质（MIS）的主要功能是启动雄性个体中缪勒管结构的退化，这是正常性发育的一部分。随着我们对其其他作用了解得越来越多，尤其是它对性腺内细胞类型生长和分化的影响，更深入地了解MIS刺激的受体以及与之相互作用的下游信号级联反应，将有助于开发MIS的诊断和治疗用途。
