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神经源性高胆固醇血症中的肝脏胆固醇-7α-羟化酶活性

Hepatic cholesterol-7alpha-hydroxylase activity in neurogenic hypercholesterolemia.

作者信息

St George S, Friedman M, Byers S O, Neuman R

出版信息

Atherosclerosis. 1976 Sep;24(3):387-92. doi: 10.1016/0021-9150(76)90131-3.

DOI:10.1016/0021-9150(76)90131-3
PMID:971342
Abstract

The cholesterol-7alpha-hydroxylase activity of hepatic microsomal preparations of hypothalamic hypercholesterolemic rats and normal rats was assayed in rats fed diets high and low in cholesterol, and in rats killed at the supposed height and at the nadir of the diurnal cycle of enzyme activity. The activity of this enzyme system appeared to be unimpaired in the hypothalamic hypercholesterolemic rat.

摘要

在下丘脑性高胆固醇血症大鼠和正常大鼠的肝微粒体制剂中，测定了喂食高胆固醇和低胆固醇饮食的大鼠，以及在假定的酶活性昼夜周期的峰值和谷值时处死的大鼠的胆固醇7α-羟化酶活性。该酶系统的活性在下丘脑性高胆固醇血症大鼠中似乎未受损害。

相似文献

1
Hepatic cholesterol-7alpha-hydroxylase activity in neurogenic hypercholesterolemia.神经源性高胆固醇血症中的肝脏胆固醇-7α-羟化酶活性
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2
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