Nikkila E A, Miettinen T A, Lanner A
Atherosclerosis. 1976 Sep;24(3):407-19. doi: 10.1016/0021-9150(76)90133-7.
The efficacy of an anion-exchange gel, Secholex, as a hypocholesterolemic agent was assessed in 46 patients in 4 different studies and the effects were compared with those of cholestyramine. All patients had severe Type II-a or II-b hyperlipoproteinemia. In short-term metabolic studies Secholex (15 g/day) and cholestyramine (16 g/day) decreased serum cholesterol levels and increased total fecal sterol output and serum methyl sterol concentration to a similar extent, but cholestyramine was more effective than Secholex in increasing fecal bile acid excretion. In crossover studies, the two drugs appeared to be equally effective in lowing serum cholesterol levels but the patients mostly preferred Secholex. Twenty patients were treated with Secholex over a two-year period. The average decrease in serum cholesterol levels from the mean pretreatment value of 406 mg/100 ml was 15% during the first year, and 13% during the second year. In 5 patients the serum cholesterol was permanently lowered by more than 20% (good responders), while in 7 patients the average reduction of serum cholesterol level during Secholex administration was less than 10% (non-responders). The serum triglyceride level was slightly decreased by Secholex in Type II-b patients but was unaltered in Type II-a patients. At the end of the treatment period, serum iron and vitamin B12 levels were normal but the serum folic acid concentration was reduced in eight of 20 patients. A dose--response study indicated that a similar cholesterol-lowering effect was obtained with daily doses of 9 and 15 g of Secholex. It is concluded that Secholex is a relatively safe drug which effectively reduces serum cholesterol levels in two-thirds of patients with severe hypercholesterolemia.
在4项不同研究中，对46例患者评估了阴离子交换凝胶Secholex作为降胆固醇药物的疗效，并将其效果与消胆胺进行了比较。所有患者均患有严重的II - a型或II - b型高脂蛋白血症。在短期代谢研究中，Secholex（15克/天）和消胆胺（16克/天）降低血清胆固醇水平、增加粪便总固醇排出量以及血清甲基固醇浓度的程度相似，但在增加粪便胆汁酸排泄方面，消胆胺比Secholex更有效。在交叉研究中，两种药物在降低血清胆固醇水平方面似乎同样有效，但患者大多更喜欢Secholex。20例患者接受了为期两年的Secholex治疗。血清胆固醇水平从治疗前平均406毫克/100毫升的数值开始，第一年平均下降15%，第二年下降13%。5例患者的血清胆固醇永久性降低超过20%（良好反应者），而7例患者在服用Secholex期间血清胆固醇水平的平均降低幅度小于10%（无反应者）。Secholex使II - b型患者的血清甘油三酯水平略有下降，但对II - a型患者无影响。治疗期末，血清铁和维生素B12水平正常，但20例患者中有8例血清叶酸浓度降低。一项剂量反应研究表明，每日服用9克和15克Secholex可获得相似的降胆固醇效果。结论是，Secholex是一种相对安全的药物，能有效降低三分之二严重高胆固醇血症患者的血清胆固醇水平。
