Mussio P, Weber W, Brunetti D, Stemmermann G N, Torhorst J
Clinical Cancer Research Unit, Practice for Medical Oncology, Basel, Switzerland.
Anticancer Res. 1998 Jul-Aug;18(4B):2811-4.
A one-page family history questionnaire was validated in two European areas covered by population-based cancer registries. Information on malignant tumor occurrence in first degree relatives was collected from 193 cancer patients in Trieste, Italy and from 64 in Basel, Switzerland. They were then compared with the corresponding data stored in the registries' files. The sensitivity of the questionnaire was 85% (Trieste) and 74% (Basel), the specificity was 97% in both studies and the overall accuracy 95% (Trieste) and 94% (Basel). The questionnaire is recommended for use in different geographical areas covered by population based registries for comparative analyses of cancer related family histories.
一份单页的家族病史调查问卷在两个有基于人群的癌症登记处覆盖的欧洲地区得到验证。在意大利的里雅斯特,从193名癌症患者那里收集了关于一级亲属恶性肿瘤发生情况的信息,在瑞士巴塞尔,从64名癌症患者那里收集了相关信息。然后将这些信息与登记处档案中存储的相应数据进行比较。该调查问卷在的里雅斯特的敏感性为85%,在巴塞尔为74%;在两项研究中特异性均为97%,总体准确率在的里雅斯特为95%,在巴塞尔为94%。建议在有基于人群的登记处覆盖的不同地理区域使用该调查问卷,以对癌症相关家族病史进行比较分析。