López-García J C
Center for Neurobiology and Behavior, Columbia University, NY 10032, USA.
Neurobiology (Bp). 1998;6(1):75-98.
Several forms of long-term potentiation (LTP), a putative cellular mechanism for memory storage, have been described in the hippocampus. In this review, I discuss the mechanisms of induction and expression of LTP at the Schaffer collateral synapses and at the mossy fiber pathway. The early biochemical steps responsible for LTP at these two pathways are well understood. However, future studies should transcend the study of signal transduction systems and focus on the identification of the synaptic proteins that experience activity-dependent modifications, ultimate effectors of the plastic changes.
长期增强作用（LTP）有多种形式，这是一种被认为与记忆存储有关的细胞机制，已在海马体中得到描述。在这篇综述中，我将探讨在谢弗侧支突触和苔藓纤维通路中LTP的诱导和表达机制。这两条通路中负责LTP的早期生化步骤已得到充分了解。然而，未来的研究应超越信号转导系统的研究，专注于识别经历活性依赖修饰的突触蛋白，即可塑性变化的最终效应器。
