Scott D B, Littlewood D G, Covino B G, Drummond G B
Br J Anaesth. 1976 Sep;48(9):899-902. doi: 10.1093/bja/48.9.899.
Plasma concentrations of lignocaine were measured in three groups of anaesthetized patients following spraying of the trachea and larynx with a lignocaine 10% aerosol spray. Greater venous plasma concentrations occurred in patients who were paralysed with suxamethonium. A mean plasma concentration of 0.1 mug/ml of lignocaine resulted from each 10 mg of lignocaine used in spontaneously breathing patients, and 0.15 mug/ml in paralysed patients. In individual patients a concentration 50% in excess of the mean value may occur. The use of lignocaine 100 mg as a 10% aerosol spray can be considered safe.
在三组麻醉患者中，用10%利多卡因气雾剂喷雾气管和喉部后，测量了血浆利多卡因浓度。使用琥珀酰胆碱麻痹的患者静脉血浆浓度更高。在自主呼吸患者中，每使用10mg利多卡因，血浆平均浓度为0.1μg/ml，而在麻痹患者中为0.15μg/ml。在个别患者中，浓度可能超过平均值50%。将100mg利多卡因作为10%气雾剂喷雾使用可认为是安全的。
