Boman H G
Karolinska Institutet, Stockholm, Sweden.
Scand J Immunol. 1998 Jul;48(1):15-25. doi: 10.1046/j.1365-3083.1998.00343.x.
Antibacterial peptides were first considered rather species-specific. However, the perspective began to change in 1987-89. Five years later there were two symposium volumes and several reviews on gene-encoded peptide antibiotics which covered the known peptides irrespective of origin. The field is rapidly growing and a first update was published in this Journal in 1996. At that time a database was made with about 100 entries; now it has over 400, with some redundancy. Recently a methodological handbook was published and there are many specialized reviews covering only defensins or insect immunity. In the last 2 years, the larger perspective of innate immunity and the role of gene-mediated peptide antibiotics have evolved in ways which justify a new update. Today insects and plants are known to have similar overall design of their defensins while insects and mammals have very similar control mechanisms. The signal pathways are beginning to appear and the future perspective may involve additional changes.
抗菌肽最初被认为具有相当的物种特异性。然而，这种观点在1987年至1989年间开始发生变化。五年后，出现了两卷专题研讨会论文集以及几篇关于基因编码肽抗生素的综述，这些综述涵盖了已知的肽，而不论其来源如何。该领域正在迅速发展，1996年在本杂志上发表了首次更新内容。当时建立了一个约有100条记录的数据库；现在它有400多条，存在一些冗余。最近出版了一本方法手册，还有许多专门的综述，仅涵盖防御素或昆虫免疫。在过去的两年里，先天免疫的更广阔视角以及基因介导的肽抗生素的作用已经以一种有理由进行新更新的方式发展。如今已知昆虫和植物的防御素具有相似的总体设计，而昆虫和哺乳动物具有非常相似的控制机制。信号通路开始显现，未来的前景可能还会有更多变化。
