Pan G, Bauer J H, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal B B, Ni J, Dixit V M
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA.
FEBS Lett. 1998 Jul 24;431(3):351-6. doi: 10.1016/s0014-5793(98)00791-1.
Tumor nectosis factor (TNF) receptors are key players in inflammation and immune regulation. A new member of this family, termed death receptor-6 (DR6), has been identified. Like other death receptors, DR6 is a type I transmembrane receptor, possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is expressed in most human tissues and abundant transcript was detected in heart, brain, placenta, pancreas, thymus, lymph node and several non-lymphoid cancer cell lines. DR6 interacts with TRADD, which has previously been shown to associate with TNFR1. Furthermore, ectopic expression of DR6 in mammalian cells induces apoptosis and activation of both NF-kappaB and JNK.
肿瘤坏死因子（TNF）受体是炎症和免疫调节中的关键因子。该家族的一个新成员，称为死亡受体-6（DR6），已被鉴定出来。与其他死亡受体一样，DR6是一种I型跨膜受体，具有四个富含半胱氨酸的细胞外基序和一个细胞质死亡结构域。DR6在大多数人类组织中表达，并且在心脏、大脑、胎盘、胰腺、胸腺、淋巴结和几种非淋巴细胞癌细胞系中检测到丰富的转录本。DR6与TRADD相互作用，TRADD先前已被证明与TNFR1相关。此外，DR6在哺乳动物细胞中的异位表达诱导细胞凋亡以及NF-κB和JNK的激活。
