Kearns B G, Alb J G, Bankaitis V
Dept of Cell Biology, University of Alabama at Birmingham 35294-0005, USA.
Trends Cell Biol. 1998 Jul;8(7):276-82. doi: 10.1016/s0962-8924(98)01281-1.
Phosphatidylinositol transfer proteins (PITPs) have historically been thought to help execute lipid-sorting events by transporting phospholipid monomers between membrane bilayers. Recent data, however, indicate unanticipated roles for PITPs in the coordination and/or coupling of phospholipid metabolism with vesicle trafficking and the downregulation of signal-transduction reactions. We are only now beginning to appreciate both the identities of PITP-dependent cellular reactions and the intriguing mechanisms by which PITPs execute their functions in eukaryotic cells.
磷脂酰肌醇转移蛋白（PITPs）在历史上一直被认为是通过在膜双层之间转运磷脂单体来协助执行脂质分选事件。然而，最近的数据表明，PITPs在磷脂代谢与囊泡运输的协调和/或偶联以及信号转导反应的下调中发挥了意想不到的作用。直到现在，我们才开始了解依赖PITP的细胞反应的特性以及PITPs在真核细胞中执行其功能的有趣机制。
