Chiba S, Simmons T W, Levy M N, Zieske H A
Cardiovasc Res. 1976 Sep;10(5):574-81. doi: 10.1093/cvr/10.5.574.
The magnitude of overdrive suppression of the SA nodal pacemaker activity was markedly influenced by its ischaemia which was produced by occlusion of the perfusion tubing close to the sinus node artery in the in-situ and isolated canine sino-atrial node preparations. In all isolated preparations, postdrive suppression was significantly augmented after occlusion of the perfusion system for at least 120 seconds. It is concluded that total ischaemia depresses sino-atrial node function in the atropinized canine heart and that postdrive suppression is a good index of such impaired function.
窦房结起搏活动的超速抑制程度受到其缺血的显著影响，这种缺血是通过在原位和离体犬窦房结标本中靠近窦房结动脉处阻塞灌注管来产生的。在所有离体标本中，灌注系统阻塞至少120秒后，驱动后抑制明显增强。得出的结论是，完全缺血会抑制阿托品化犬心脏中的窦房结功能，并且驱动后抑制是这种功能受损的一个良好指标。
