Gimble J M, Robinson C E, Clarke S L, Hill M R
Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
Crit Rev Eukaryot Gene Expr. 1998;8(2):141-68. doi: 10.1615/critreveukargeneexpr.v8.i2.30.
Adipocytes provide a model cell system for exploring the complexities of nuclear hormone receptor transcriptional regulation. Adipocytes produce lipid and cholesterol metabolites which can serve as activating ligands for many of the classic and "orphan" nuclear hormone receptors. At the same time, nuclear hormone receptors directly control adipocyte commitment. The recently described nuclear hormone receptor coactivators and corepressors provide an additional level of complexity to this system. This review emphasizes available in vitro and in vivo models and discusses them in the context of current controversies and future experimental directions.
脂肪细胞为探索核激素受体转录调控的复杂性提供了一个模型细胞系统。脂肪细胞产生脂质和胆固醇代谢产物，这些产物可作为许多经典和“孤儿”核激素受体的激活配体。同时，核激素受体直接控制脂肪细胞的定向分化。最近描述的核激素受体共激活因子和共抑制因子为该系统增添了额外的复杂性。本综述重点介绍了现有的体外和体内模型，并在当前争议和未来实验方向的背景下对它们进行了讨论。
