Schissel D J, Hivnor C, Elston D M
Department of Dermatology, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200, USA.
Cutis. 1998 Aug;62(2):77-80.
Elephantiasis nostras verrucosa is a rare, chronic, deforming disorder characterized by hyperkeratosis and papillomatosis of the epidermis with underlying woody fibrosis of the dermis and subcutaneous tissue. Chronic lymphedema, either congenital or secondary to infection, surgery, radiation, neoplastic obstruction, obesity, portal hypertension, or chronic congestive heart failure, plays a pivotal role in the pathogenesis. Without appropriate intervention, the slowly progressive cutaneous changes will culminate in massive and grotesque enlargement of the affected body region. In the following case report, the natural history and the management of elephantiasis nostras are discussed.
疣状 nostras 象皮病是一种罕见的慢性致残性疾病，其特征为表皮角化过度和乳头瘤病，伴有真皮和皮下组织的木样纤维化。先天性或继发于感染、手术、放疗、肿瘤阻塞、肥胖、门静脉高压或慢性充血性心力衰竭的慢性淋巴水肿在发病机制中起关键作用。若不进行适当干预，皮肤的缓慢进展性改变最终会导致受累身体部位出现巨大且怪异的肿大。在以下病例报告中，将讨论疣状 nostras 象皮病的自然病程及治疗方法。
