Yeo E L, Yu K M, Poddar N C, Hui P K, Tang L C
Department of Obstetrics and Gynaecology, Kwong Wah Hospital, Kowloon, Hong Kong SAR, China.
J Obstet Gynaecol Res. 1998 Jun;24(3):189-95. doi: 10.1111/j.1447-0756.1998.tb00074.x.
A retrospective study of 316 ovarian neoplasms which had frozen section evaluation between January 1, 1990 to December 31, 1995 was conducted to determine the accuracy of frozen section diagnosis of ovarian neoplasms. The frozen section results were compared with final diagnoses from paraffin sections. The frozen section diagnosis was accurate in 95.2% of all cases and inaccurate in 4.8%. The positive predictive value of a positive (or malignant) frozen section was 100%, the negative predictive value of a negative (or benign) frozen section was 98.2%. The sensitivity for malignant tumors as 87%. For tumors of borderline malignancy, the sensitivity and specificity were 60% and 98.6% respectively. Of the false negative frozen section diagnoses, 73% (8 cases) occurred in tumors of borderline malignancy. We concluded that with the exception of the sensitivity for the diagnosis of tumors of borderline malignancy, the sensitivity and specificity of frozen section diagnosis for benign and overtly malignant ovarian neoplasms are high.
对1990年1月1日至1995年12月31日期间进行了冰冻切片评估的316例卵巢肿瘤进行了一项回顾性研究，以确定卵巢肿瘤冰冻切片诊断的准确性。将冰冻切片结果与石蜡切片的最终诊断结果进行比较。在所有病例中，冰冻切片诊断准确的占95.2%，不准确的占4.8%。阳性（或恶性）冰冻切片的阳性预测值为100%，阴性（或良性）冰冻切片的阴性预测值为98.2%。恶性肿瘤的敏感性为87%。对于交界性恶性肿瘤，敏感性和特异性分别为60%和98.6%。在冰冻切片假阴性诊断中，73%（8例）发生在交界性恶性肿瘤中。我们得出结论，除了对交界性恶性肿瘤诊断的敏感性外，冰冻切片诊断对良性和明显恶性卵巢肿瘤的敏感性和特异性都很高。
