Siewert-Delle A, Ljungman S
Department of Nephrology, Sahlgrenska University Hospital, Göteborg University, Sweden.
Am J Hypertens. 1998 Aug;11(8 Pt 1):946-53. doi: 10.1016/s0895-7061(98)00090-9.
The impact of birth weight and gestational age on blood pressure in adult life was studied in a population of 49-year-old men born in 1926-27 who took part in a screening investigation of blood pressure performed in 1975-76 in Göteborg, Sweden. Birth records were traced in 430 subjects and compared with screening records. The adult systolic blood pressure (SBP) was not correlated with birth weight but was inversely correlated with gestational age in the whole study group (r = -0.10, P = .04; n = 430). The correlation between adult blood pressure and gestational age was stronger in preterm subjects, ie, those with a gestational age less than 38 weeks (for SBP, r = -0.46, P = .001 and for diastolic blood pressure [DBP], r = -0.44, P = .01; n = 44), and these correlations were independent of birth weight. There was, however, no correlation between adult blood pressure and gestational age in subjects born at term (between 38 and 41 complete weeks of gestation) or postterm (more than 42 weeks of gestation). The inverse correlation between adult SBP and gestational age was stronger in low-birth-weight subjects (< or = 2500 g; r = -0.86, P < .001; n = 14). After adjustment for birth weight, in this group an increase by 1 week of gestation was associated with a decrease in adult SBP of 7.2 mm Hg (95% CI, 10.1-4.2). In the whole study group, a positive correlation was found between adult blood pressure and adult body mass index (BMI) (r = 0.30, P < .001 for SBP and r = 0.33, P < .001 for DBP). In preterm subjects, however, no such correlation was found, but in subjects born at term or postterm, adult blood pressure was significantly correlated with BMI (for SBP at term, r = 0.34, P < .001 and postterm, r = 0.47, P < .001 and for DBP at term, r = 0.36, P < .001 and postterm, r = 0.30, P < .05). This study indicates that adult blood pressure appears to be related to different variables in different ranges of gestation. In preterm subjects, gestational age appears to have a great impact on adult blood pressure. In subjects born at term or later, however, adult blood pressure was not associated with factors related to birth, but only to the adult BMI.
对1926年至1927年出生、1975年至1976年在瑞典哥德堡参加血压筛查调查的49岁男性人群，研究了出生体重和胎龄对成年后血压的影响。在430名受试者中追溯出生记录并与筛查记录进行比较。在整个研究组中，成人收缩压（SBP）与出生体重无相关性，但与胎龄呈负相关（r = -0.10，P = 0.04；n = 430）。成人血压与胎龄之间的相关性在早产受试者（即胎龄小于38周的受试者）中更强（对于SBP，r = -0.46，P = 0.001；对于舒张压[DBP]，r = -0.44，P = 0.01；n = 44），且这些相关性独立于出生体重。然而，足月出生（妊娠38至41整周）或过期产（妊娠超过42周）的受试者中，成人血压与胎龄无相关性。成人SBP与胎龄之间的负相关性在低出生体重受试者（≤2500 g；r = -0.86，P < 0.001；n = 14）中更强。在该组中，调整出生体重后，妊娠增加1周与成人SBP降低7.2 mmHg相关（95% CI，10.1 - 4.2）。在整个研究组中，发现成人血压与成人身体质量指数（BMI）呈正相关（对于SBP，r = 0.30，P < 0.001；对于DBP，r = 0.33，P < 0.001）。然而，在早产受试者中未发现这种相关性，但在足月或过期产出生的受试者中，成人血压与BMI显著相关（足月时SBP，r = 0.34，P < 0.001；过期产时，r = 0.47，P < 0.001；足月时DBP，r = 0.36，P < 0.001；过期产时，r = 0.30，P < 0.05）。本研究表明，成人血压似乎在不同妊娠范围内与不同变量相关。在早产受试者中，胎龄似乎对成人血压有很大影响。然而，在足月或更晚出生的受试者中，成人血压与出生相关因素无关，而仅与成人BMI有关。
