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伦敦脐带血库。

The London Cord Blood Bank.

作者信息

Navarrete C, Warwick R, Armitage S, Fehily D, Contreras M

机构信息

The London Cord Blood Bank, UK.

出版信息

Bone Marrow Transplant. 1998 Jul;22 Suppl 1:S6-7.

PMID:9715869
Abstract

Cord blood (CB) contains a sufficient number of haemopoietic progenitor cells and can be used as an alternative to bone marrow transplantation. To date, a number of transplants using cord blood-derived stem cells from HLA-identical siblings and unrelated donors have been successfully performed. However, only approximately 30% of patients have an HLA-identical sibling while the rest are reliant on finding an HLA-compatible unrelated donor. This is particularly difficult for patients from ethnic minorities since the majority of unrelated bone marrow donor volunteers are from Caucasoid ancestry. The London Cord Blood Bank was established to provide an additional source of stem cells for all patients requiring bone marrow transplantation.

摘要

脐血(CB)含有足够数量的造血祖细胞,可作为骨髓移植的替代方法。迄今为止,已经成功进行了许多使用来自 HLA 相同的同胞和无关供体的脐血干细胞的移植手术。然而,只有约 30% 的患者有 HLA 相同的同胞,其余患者则依赖于找到 HLA 匹配的无关供体。这对于少数族裔患者来说尤其困难,因为大多数无关骨髓供体志愿者来自高加索血统。伦敦脐血库的建立是为了为所有需要骨髓移植的患者提供额外的干细胞来源。

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