Systemic lupus erythematosus in a naval aviator--its aeromedical implications.

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease, characterized by immune dysregulation resulting in the production of antinuclear antibodies (ANA), generation of circulating immune complexes, and activation of the complement system. SLE is notable for its broad spectrum of clinical manifestations and a variable course characterized by exacerbations and remissions. The pathologic hallmark of the disease is recurrent, widespread, and diverse vascular lesions. This multisystem affliction is unpredictable and brings many aeromedical and occupational health issues that need careful consideration in the differential diagnosis of a patient with symmetrical joint pain or facial rash.