重度抑郁症患者外周血白细胞的粘附性/聚集性升高。

Elevated adhesiveness/aggregation of peripheral blood leukocytes in patients with major depression.

作者信息

Zemishlany Z, Aizenberg D, Klein C, Modai I, Aronson M, Weizman A

机构信息

Geha Psychiatric Hospital, Rabin Medical Center, Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Israel.

出版信息

J Affect Disord. 1998 Jul;50(1):3-9. doi: 10.1016/s0165-0327(98)00036-6.

DOI:10.1016/s0165-0327(98)00036-6

PMID:9716272

Abstract

A simple slide test was used to determine the effects of major depression (MD) and heterocyclic antidepressants on leukocyte adhesiveness/aggregation (LAA) in the peripheral blood. Eighty subjects were categorized into four equal groups: untreated-MD patients, treated-MD patients, nondepressed patients treated with antidepressants and healthy controls. Significantly higher LAA values were observed both in untreated- and treated-MD patients, 13.8+/-1.7% and 13.5+/-1.9% respectively, compared to nondepressed-treated patients and healthy controls, 5.4+/-0.9% and 6.4+/-0.7% respectively (P < 0.0001). Increased LAA was associated with the depressive episode, was not affected by antidepressants and may potentially serve as a useful laboratory state marker for MD.

摘要

采用一种简单的玻片试验来确定重度抑郁症（MD）和杂环类抗抑郁药对外周血中白细胞黏附/聚集（LAA）的影响。80名受试者被分为四组，每组人数相等：未治疗的MD患者、已治疗的MD患者、服用抗抑郁药的非抑郁患者和健康对照组。与非抑郁治疗患者和健康对照组相比，未治疗和已治疗的MD患者的LAA值显著更高，分别为13.8±1.7%和13.5±1.9%，而非抑郁治疗患者和健康对照组分别为5.4±0.9%和6.4±0.7%（P<0.0001）。LAA增加与抑郁发作相关，不受抗抑郁药影响，可能作为MD的一种有用的实验室状态标志物。