Powell F L, Milsom W K, Mitchell G S
Department of Medicine and White Mountain Research Station University of California, San Diego, La Jolla 92093-0623, USA.
Respir Physiol. 1998 May;112(2):123-34. doi: 10.1016/s0034-5687(98)00026-7.
The ventilatory response to hypoxia depends on the pattern and intensity of hypoxic exposure and involves several physiological mechanisms. These mechanisms differ in their effect (facilitation or depression) on different components of ventilation (tidal volume and frequency) and in their time course (seconds to years). Some mechanisms last long enough to affect future ventilatory responses to hypoxia, indicating 'memory' or functional plasticity in the ventilatory control system. A standard terminology is proposed to describe the different time domains of the hypoxic ventilatory response (HVR) and to promote integration of results from different experimental preparations and laboratories. In general, the neurophysiological and neurochemical basis for short time domains of the HVR (seconds and minutes) are understood better than longer time domains (days to years), primarily because short time domains are studied in the laboratory more easily. Understanding the mechanisms for different time domains of the HVR has important implications for both basic and clinical science.
对缺氧的通气反应取决于缺氧暴露的模式和强度，并涉及多种生理机制。这些机制对通气的不同组成部分（潮气量和频率）的影响（促进或抑制）以及其时间进程（从秒到年）各不相同。一些机制持续时间足够长，足以影响未来对缺氧的通气反应，这表明通气控制系统中存在“记忆”或功能可塑性。本文提出了一个标准术语，用于描述缺氧通气反应（HVR）的不同时间域，并促进不同实验制剂和实验室结果的整合。一般来说，HVR短时间域（秒和分钟）的神经生理学和神经化学基础比长时间域（天到年）的理解更好，主要是因为短时间域在实验室中更容易研究。了解HVR不同时间域的机制对基础科学和临床科学都具有重要意义。
