锌指基因Zfp105在精子发生过程中的差异表达。

Differential expression of the zinc finger gene Zfp105 during spermatogenesis.

作者信息

Przyborski S A, Knowles B B, Handel M A, Gurwitch S A, Ackerman S L

机构信息

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

出版信息

Mamm Genome. 1998 Sep;9(9):758-62. doi: 10.1007/s003359900859.

DOI:10.1007/s003359900859

PMID:9716663

Abstract

We report the isolation of Zfp105, the mouse homolog of the human ZNF35 zinc finger gene. Zfp105 and ZNF35 are highly conserved at the protein and nucleotide level, and Zfp105 maps to a region of mouse Chromosome (Chr) 9 that is homologous to the human region containing ZNF35. Zpf105 is highly expressed in the testis, especially in pachytene spermatocytes and round spermatids. The possible role of this gene product in maintaining an ordered germ cell differentiation process is discussed.

摘要

我们报道了Zfp105的分离，它是人类ZNF35锌指基因的小鼠同源物。Zfp105和ZNF35在蛋白质和核苷酸水平上高度保守，并且Zfp105定位于小鼠9号染色体（Chr）上与包含ZNF35的人类区域同源的区域。Zpf105在睾丸中高度表达，尤其是在粗线期精母细胞和圆形精子细胞中。本文讨论了该基因产物在维持有序的生殖细胞分化过程中的可能作用。