Jørgensen B, Endresen K, Forfang K, Simonsen S, Thaulow E
Department of Cardiology, University of Oslo, Norway.
Eur Heart J. 1998 May;19(5):737-41. doi: 10.1053/euhj.1997.0836.
To study the impact of smoking on the change in exercise capacity in patients treated with coronary angioplasty.
Three hundred and sixty-eight men below 70 years of age eligible for percutaneous transluminal coronary angioplasty without previous coronary interventions were consecutively enrolled. Of the 334 patients (90.8%) who completed the study 77 (23.1%) were current smokers. Exercise tests were performed before percutaneous transluminal coronary angioplasty, 2 and 19 +/- 2.4 weeks after percutaneous transluminal coronary angioplasty. Coronary angiography was done in 333 patients (99.7%) (at mean 19 +/- 2.4 weeks). The angiograms were analysed quantitatively.
There were no differences in the clinical and angiographic characteristics among the groups except for age. The non-smokers were older than the smokers (55.7 vs 52.4 years (P = 0.001)). Exercise capacity was equal before percutaneous transluminal coronary angioplasty in both groups (17.6 vs 16.5 W x min-1 x kg-1). Non-smokers had a significantly higher increase in exercise capacity than smokers from baseline to 2 weeks after percutaneous transluminal coronary angioplasty (mean difference 4.3 W x min-1 x kg-1 (95% CI: 2.3 to 6.2; P < 0.001)), and from baseline to 19 weeks after percutaneous transluminal coronary angioplasty (mean difference 3.9 W x min-1 x kg-1 (95% CI: 1.6 to 6.2; P < 0.001).
A clinical benefit from percutaneous transluminal coronary angioplasty was seen in both groups as judged from exercise testing. Smokers had a substantially lower increase in exercise capacity than non-smokers, indicating an attenuated benefit from percutaneous transluminal coronary angioplasty among smokers.
研究吸烟对接受冠状动脉血管成形术患者运动能力变化的影响。
连续纳入368名年龄在70岁以下、符合经皮腔内冠状动脉血管成形术条件且既往未接受过冠状动脉干预的男性。在完成研究的334名患者（90.8%）中，77名（23.1%）为当前吸烟者。在经皮腔内冠状动脉血管成形术前、术后2周以及术后19±2.4周进行运动测试。333名患者（99.7%）进行了冠状动脉造影（平均在术后19±2.4周）。对血管造影图像进行定量分析。
除年龄外，各组间临床和血管造影特征无差异。非吸烟者比吸烟者年龄更大（55.7岁对52.4岁，P = 0.001）。两组在经皮腔内冠状动脉血管成形术前运动能力相当（17.6对16.5瓦·分钟⁻¹·千克⁻¹）。从基线到经皮腔内冠状动脉血管成形术后2周，非吸烟者运动能力的增加显著高于吸烟者（平均差异4.3瓦·分钟⁻¹·千克⁻¹，95%可信区间：2.3至6.2；P < 0.
