双硫仑对苯妥英钠和甲苯磺丁脲在人体内半衰期及代谢清除率的影响。
The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbtamide in man.
作者信息
Svendsen T L, Kristensen M B, Hansen J M, Skovsted L
出版信息
Eur J Clin Pharmacol. 1976 Mar 22;09(5-6):439-41. doi: 10.1007/BF00606562.
PMID:971708
Abstract
Diphenylhydantoin (DPH) and tolbutamide serum levels were studied in ten volunteers before and after 4 days of disulfiram treatment. The mean DPH half life increased significantly from 11.0 +/- a.2 h to 19.0 +/- 3.3 h, and the mean DPH metabolic clearance rate decreased significantly from 51.2 +/- 17.2 ml/min to 33.9 +/- 12.0 ml/min during medication. No significant changes in the half life or metabolic clearance rate of tolbutamide was observed.
摘要
在十名志愿者中，研究了双硫仑治疗4天前后的苯妥英（DPH）和甲苯磺丁脲的血清水平。服药期间，平均DPH半衰期从11.0±2.2小时显著增加至19.0±3.3小时，平均DPH代谢清除率从51.2±17.2毫升/分钟显著降至33.9±12.0毫升/分钟。未观察到甲苯磺丁脲半衰期或代谢清除率的显著变化。
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