犬猫感染性疾病和淋巴造血系统肿瘤的骨髓变化——一项回顾性研究

Bone-marrow changes in infectious diseases and lymphohaemopoietic neoplasias in dogs and cats--a retrospective study.

作者信息

Breuer W, Stahr K, Majzoub M, Hermanns W

机构信息

Institute of Veterinary Pathology, University of Munich, Germany.

出版信息

J Comp Pathol. 1998 Jul;119(1):57-66. doi: 10.1016/s0021-9975(98)80071-6.

DOI:10.1016/s0021-9975(98)80071-6

PMID:9717127

Abstract

Bone-marrow changes in infectious diseases due to feline infectious peritonitis virus (FIPV), feline immunodeficiency virus (FIV), parvovirus (PV, canine and feline) and canine distemper virus (CDV), and in the lymphohaemopoietic neoplasias (LHNs) usually associated with feline leukaemia virus infection were studied in samples obtained from 204 cats and 82 dogs at necropsy. The study demonstrated (1) no changes, (2) non-specific reactive changes, and (3) disease-specific changes (similar to those occurring in extramedullary sites) in: 51.2, 48.8 and 9.7% of 41 cases of FIPV infection, respectively; 0, 100 and 0% of nine cases of FIV infection, respectively; 1.3, 0 and 92% of 75 cases of canine PV infection, respectively; 5.3, 3.9 and 84% of 76 cases of feline PV infection, respectively; 71.4, 28.6 and 0% of seven cases of CDV infection, respectively; and 35.9, 52.6 and 11.5% of 78 cases of LHN, respectively. The distribution of the disease-specific bone-marrow changes was either diffuse or focal; diffuse changes were frequently found in cases of feline and canine PV infection, and focal changes were found inconsistently in FIPV infections and feline LHN. To the extent that the bone marrow showed any changes in FIV and CDV infections, they were mostly reactive and not pathognomonic.

摘要

对204只猫和82只狗尸检时获取的样本进行研究，观察猫传染性腹膜炎病毒（FIPV）、猫免疫缺陷病毒（FIV）、细小病毒（PV，犬和猫）及犬瘟热病毒（CDV）所致传染病的骨髓变化，以及通常与猫白血病病毒感染相关的淋巴造血系统肿瘤（LHN）的骨髓变化。该研究显示，在41例FIPV感染病例中，分别有51.2%、48.8%和9.7%的病例出现：（1）无变化，（2）非特异性反应性变化，（3）疾病特异性变化（类似于髓外部位出现的变化）；在9例FIV感染病例中，分别有0%、100%和0%出现上述情况；在75例犬PV感染病例中，分别有1.3%、0%和92%出现上述情况；在76例猫PV感染病例中，分别有5.3%、3.9%和84%出现上述情况；在7例CDV感染病例中，分别有71.4%、28.6%和0%出现上述情况；在78例LHN病例中，分别有35.9%、52.6%和11.5%出现上述情况。疾病特异性骨髓变化的分布为弥漫性或局灶性；弥漫性变化常见于猫和犬PV感染病例，局灶性变化在FIPV感染和猫LHN病例中出现情况不一。就FIV和CDV感染时骨髓出现的任何变化而言，大多为反应性变化，并非特征性变化。