Segal G, Shuman H A
Dept of Microbiology, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
Trends Microbiol. 1998 Jul;6(7):253-5. doi: 10.1016/s0966-842x(98)01308-0.
The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to constitute components of a conjugal transfer system that has been adopted to prevent phagosome-lysosome fusion in the host cell and to mediate host cytotoxicity by pore formation. Whether these functions are natural consequences or operate in parallel remains to be discovered.
以下两篇文章，第一篇由吉尔·西格尔和霍华德·舒曼撰写，第二篇由詹姆斯·柯比和拉尔夫·伊斯伯格撰写（《微生物学趋势》6卷，256 - 258页），探讨了嗜肺军团菌icm/dot基因的遗传学和功能。这个基因家族与毒力的多个方面有关，似乎构成了一个接合转移系统的组成部分，该系统已被用于防止宿主细胞中的吞噬体 - 溶酶体融合，并通过形成孔道介导宿主细胞毒性。这些功能是自然结果还是并行发挥作用仍有待发现。
