Abelló P, Viñas J B, Vega J
Hospital de la Sta, Creu i St. Pau, Barcelona.
Acta Otorrinolaringol Esp. 1998 Jun-Jul;49(5):353-6.
Over a six-year period, 6 cases of local toxicity produced by gentamicin and dexamethasone ear drops were observed in Sant Pau Hospital, Barcelona. No cases due to neomycin or polymixin B were seen. All patients consulted for dizziness. Audiometric and vestibular examination revealed only involvement of the vestibular labyrinth and recovery was spontaneous. Most cases occurred during prolonged treatment without medical control and patients had extensive tympanic perforation or suppuration had ceased. In contrast with findings in animal studies, the risk of topical toxicity in humans is limited and avoidable if the necessary precautions are taken with ear-drop prescriptions.
在六年时间里，巴塞罗那圣保罗医院观察到6例由庆大霉素和地塞米松耳滴剂引起的局部毒性反应。未发现由新霉素或多粘菌素B引起的病例。所有患者均因头晕前来就诊。听力和前庭检查显示仅前庭迷路受累，且恢复是自发的。大多数病例发生在长期治疗且无医疗监控的情况下，患者有广泛的鼓膜穿孔或化脓已停止。与动物研究结果相反，人类局部用药毒性的风险是有限的，并且如果在开具耳滴剂处方时采取必要的预防措施，是可以避免的。
