4-甲基-5-羟基戊酸诱导大鼠肝脏胆固醇合成的改变。
Alteration of cholesterol synthesis in rat liver as induced by 4-methyl-5-hydroxy valeric acid.
作者信息
Díaz-Zagoya J C, Hurtado M E, González J
出版信息
Experientia. 1976 Sep 15;32(9):1138-40. doi: 10.1007/BF01927589.
PMID:971744
Abstract
The rate of cholesterogenesis in rat liver, measured by the incorporation of labelled acetate or mevalonate into cholesterol, was significantly supressed by the use of 4-methyl-5-hydroxy valeric acid sodium salt. This effect cannot be explained by changes in HMG CoA reductase activity.
摘要
通过将标记的乙酸盐或甲羟戊酸盐掺入胆固醇来测量，大鼠肝脏中的胆固醇生成速率因使用4-甲基-5-羟基戊酸钠盐而显著受到抑制。这种效应无法用HMG CoA还原酶活性的变化来解释。
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