Mishra V K, Srivastava M K, Raizada R B
Pesticide Toxicology Laboratory, Industrial Toxicology Research Center, Lucknow, India.
Indian J Exp Biol. 1998 Apr;36(4):390-4.
Thiram was administered to male rats through gavage at doses 5, 10 and 25 mg/kg/day for 180 and 360 days. Thiram has caused marginal increase in the relative weight of testes and epididymis and decrease in the weight of seminal vesicle and prostate. Marked degenerative changes were observed in seminiferous tubules together with alterations in testicular enzyme profile. The activity of testicular enzymes such as ACP, SDH and ATPase (Na+ + K+ dependent) was decreased whereas activity of LDH, G-6-PDH and ALP increased. The levels of serum cholesterol and testicular free sialic acid were enhanced, while the level of testicular protein was lowered. It is evident from the present study that long term treatment of thiram at tested dose levels has resulted in dose and time dependent morphological and biochemical changes in testes of rat.
将福美双以5、10和25毫克/千克/天的剂量通过灌胃给予雄性大鼠，持续180天和360天。福美双已导致睾丸和附睾的相对重量略有增加，精囊和前列腺的重量减少。在生精小管中观察到明显的退行性变化，同时睾丸酶谱也发生改变。睾丸酶如酸性磷酸酶（ACP）、琥珀酸脱氢酶（SDH）和（钠+钾依赖性）ATP酶的活性降低，而乳酸脱氢酶（LDH）、葡萄糖-6-磷酸脱氢酶（G-6-PDH）和碱性磷酸酶（ALP）的活性增加。血清胆固醇和睾丸游离唾液酸水平升高，而睾丸蛋白水平降低。从本研究中可以明显看出，在测试剂量水平下长期使用福美双已导致大鼠睾丸出现剂量和时间依赖性的形态和生化变化。
