Nagda K K, Deshmukh B
Department of Biochemistry, Dr. V. M. Medical College, Solapur, India.
Indian J Exp Biol. 1998 Apr;36(4):426-8.
The usefulness of a galactose specific lectin from P. tithymaloides was examined to study the hemagglutination pattern in 193 patients with diabetes mellitus out of which 34 cases were of insulin dependent. A control of 72 normal subjects was also included. The hemagglutination titre against a partially purified lectin from P. tithymaloides of control group ranged from 9.1 to 170 units per mg protein with a mean value of 54 units per mg protein. Significantly low titre was observed in the cases with insulin dependent diabetes mellitus, while non-insulin dependent diabetes mellitus cases did not show any significant change. Further significant reduction in the titre in insulin dependent diabetes mellitus group was shown to occur along with the increased duration of the diabetic condition, reflecting measurable erythrocyte surface alterations.
对来自千根癀的半乳糖特异性凝集素的效用进行了检测，以研究193例糖尿病患者的血凝模式，其中34例为胰岛素依赖型。还纳入了72名正常受试者作为对照。对照组针对来自千根癀的部分纯化凝集素的血凝滴度范围为每毫克蛋白质9.1至170单位，平均值为每毫克蛋白质54单位。在胰岛素依赖型糖尿病患者中观察到滴度显著降低，而非胰岛素依赖型糖尿病患者未显示出任何显著变化。胰岛素依赖型糖尿病组的滴度进一步显著降低，且随着糖尿病病程的延长而出现，这反映了可测量的红细胞表面改变。
