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哮喘发作后出现的脊髓灰质炎样综合征（霍普金斯综合征）——静脉注射γ球蛋白治疗后恢复

Poliomyelitis-like syndrome following asthmatic attack (Hopkins' syndrome)--recovery associated with i.v. gamma globulin treatment.

作者信息

Cohen H A, Ashkenasi A, Ring H, Weiss R, Wolach B, Paret G, Barzilai A

机构信息

Family Medicine Dept., Lowenstein Rehabilitation Hospital, Israel.

出版信息

Infection. 1998 Jul-Aug;26(4):247-9. doi: 10.1007/BF02962374.

DOI:10.1007/BF02962374
PMID:9717685
Abstract

A report on a 15-year-old male with a diagnosis of poliomyelitis-like syndrome (Hopkins' syndrome) following an asthmatic attack is presented. The prognosis of Hopkins' syndrome is usually poor and the patients remain with permanent paralysis of the affected limb. The outcome correlates with severity of the initial injury to the anterior horn cell as reflected by abnormal electrophysiologic studies. This is the first case report of treatment with i.v. gamma globulin in Hopkins' syndrome which resulted in a nearly complete recovery.

摘要

本文报告了一名15岁男性，在哮喘发作后被诊断为脊髓灰质炎样综合征（霍普金斯综合征）。霍普金斯综合征的预后通常较差，患者受影响肢体将永久性瘫痪。预后与前角细胞初始损伤的严重程度相关，这可通过异常的电生理研究反映出来。这是首例关于静脉注射丙种球蛋白治疗霍普金斯综合征并取得近乎完全康复的病例报告。

相似文献

1
Poliomyelitis-like syndrome following asthmatic attack (Hopkins' syndrome)--recovery associated with i.v. gamma globulin treatment.哮喘发作后出现的脊髓灰质炎样综合征（霍普金斯综合征）——静脉注射γ球蛋白治疗后恢复
Infection. 1998 Jul-Aug;26(4):247-9. doi: 10.1007/BF02962374.
2
Poliomyelitis-like syndrome following asthmatic attack (Hopkins syndrome).哮喘发作后出现的脊髓灰质炎样综合征（霍普金斯综合征）。
Pediatr Neurol. 1987 May-Jun;3(3):166-8. doi: 10.1016/0887-8994(87)90085-3.
3
Flaccid paralysis of the limbs after an asthmatic attack.哮喘发作后四肢弛缓性瘫痪。
Pediatr Neurol. 2010 Feb;42(2):133-6. doi: 10.1016/j.pediatrneurol.2009.09.013.
4
Hopkins syndrome: T2-weighted high intensity of anterior horn on spinal MR imaging.霍普金斯综合征：脊髓磁共振成像T2加权像上脊髓前角高信号。
Pediatr Neurol. 1995 Oct;13(3):263-5. doi: 10.1016/0887-8994(95)00181-e.
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Acute postasthmatic amyotrophy (Hopkins' syndrome).急性哮喘后肌萎缩（霍普金斯综合征）。
Muscle Nerve. 1994 Jul;17(7):769-72. doi: 10.1002/mus.880170711.
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Recurrent Hopkin's syndrome: a case report and review of the literature.复发性霍普金斯综合征：病例报告及文献复习。
J Neurol Sci. 2010 Oct 15;297(1-2):89-91. doi: 10.1016/j.jns.2010.07.005. Epub 2010 Aug 7.
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[Hopkins' syndrome in the differential diagnosis of flaccid paralysis in children: clinical and neurophysiological features. Case report].[小儿弛缓性麻痹鉴别诊断中的霍普金斯综合征：临床及神经生理学特征。病例报告]
Arq Neuropsiquiatr. 2003 Jun;61(2B):494-8. doi: 10.1590/s0004-282x2003000300033. Epub 2003 Jul 28.
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[Hopkins syndrome: oral prednisolone was effective for the paralysis].[霍普金斯综合征：口服泼尼松龙对瘫痪有效]
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Poliomyelitis-like syndrome associated with asthma. A case report and review of the literature.与哮喘相关的脊髓灰质炎样综合征。一例病例报告及文献复习。
Arch Neurol. 1980 Jan;37(1):52-3. doi: 10.1001/archneur.1980.00500500082014.
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Poliomyelitis-like illness after acute asthma (Hopkins syndrome): a histological study of biopsied muscle in a case.急性哮喘后类似脊髓灰质炎的疾病（霍普金斯综合征）：一例活检肌肉的组织学研究
Brain Dev. 1995 Mar-Apr;17(2):126-9. doi: 10.1016/0387-7604(94)00125-h.

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Hopkins syndrome following the first episode of bronchial asthma associated with enterovirus D68: a case report.首例与肠道病毒D68相关的支气管哮喘发作后出现霍普金斯综合征：病例报告
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本文引用的文献

1
Revised recommendations for poliovirus immunization.脊髓灰质炎病毒免疫接种的修订建议。
Pediatr Infect Dis J. 1998 Feb;17(2):159-60. doi: 10.1097/00006454-199802000-00017.
2
PCR diagnosis of primary herpesvirus type I in poliomyelitis-like paralysis and respiratory tract disease.I型原发性疱疹病毒在脊髓灰质炎样麻痹和呼吸道疾病中的PCR诊断
Pediatr Neurol. 1993 May-Jun;9(3):227-9. doi: 10.1016/0887-8994(93)90091-p.
3
Acute postasthmatic amyotrophy (Hopkins' syndrome).急性哮喘后肌萎缩（霍普金斯综合征）。
Muscle Nerve. 1994 Jul;17(7):769-72. doi: 10.1002/mus.880170711.
4
Poliomyelitis-like illness after acute asthma (Hopkins syndrome): a histological study of biopsied muscle in a case.急性哮喘后类似脊髓灰质炎的疾病（霍普金斯综合征）：一例活检肌肉的组织学研究
Brain Dev. 1995 Mar-Apr;17(2):126-9. doi: 10.1016/0387-7604(94)00125-h.
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Poliomyelitis-type illness associated with severe asthma in a child.一名儿童中与重症哮喘相关的脊髓灰质炎样疾病。
J R Soc Med. 1981 Jan;74(1):71-2.
6
Immunological abnormalities in the syndrome of poliomyelitis-like illness associated with acute bronchial asthma (Hopkin's syndrome).与急性支气管哮喘相关的脊髓灰质炎样疾病综合征（霍普金斯综合征）中的免疫异常。
Arch Dis Child. 1980 Jan;55(1):26-32. doi: 10.1136/adc.55.1.26.
7
Poliomyelitis-like syndrome associated with asthma. A case report and review of the literature.与哮喘相关的脊髓灰质炎样综合征。一例病例报告及文献复习。
Arch Neurol. 1980 Jan;37(1):52-3. doi: 10.1001/archneur.1980.00500500082014.
8
Poliomyelitis-like illness associated with asthma.与哮喘相关的脊髓灰质炎样疾病
Arch Dis Child. 1980 Jan;55(1):61-3. doi: 10.1136/adc.55.1.61.
9
Measles encephalomyelitis--clinical and immunologic studies.麻疹脑脊髓炎——临床与免疫学研究
N Engl J Med. 1984 Jan 19;310(3):137-41. doi: 10.1056/NEJM198401193100301.
10
A new syndrome: poliomyelitis-like illness associated with acute asthma in childhood.一种新综合征：儿童期与急性哮喘相关的脊髓灰质炎样疾病。
Aust Paediatr J. 1974 Oct;10(5):273-6. doi: 10.1111/j.1440-1754.1974.tb02783.x.