硝普钠对大鼠肾上腺髓质儿茶酚胺合成途径的影响。

Effects of sodium nitroprusside on the catecholamine synthetic pathway in the adrenal medulla of rats.

作者信息

Kumai T, Tanaka M, Tateishi T, Asoh M, Kobayashi S

机构信息

Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

出版信息

Jpn J Pharmacol. 1998 Jul;77(3):205-10. doi: 10.1254/jjp.77.205.

DOI:10.1254/jjp.77.205

PMID:9717767

Abstract

We studied the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on tyrosine hydroxylase (TH) activity and epinephrine and norepinephrine levels in the adrenal medulla of rats. TH activity and the levels of epinephrine and norepinephrine in the adrenal medulla of the SNP+nicotine (Nic)-treated group were increased significantly compared to those in the control, Nic-treated and SNP-treated groups. Furthermore, methylene blue inhibited this increase in TH activity. The data suggest that the NO derived from SNP may increase TH through the guanylyl cyclase pathway in the presence of Nic.

摘要

我们研究了一氧化氮（NO）供体硝普钠（SNP）对大鼠肾上腺髓质中酪氨酸羟化酶（TH）活性以及肾上腺素和去甲肾上腺素水平的影响。与对照组、尼古丁（Nic）处理组和SNP处理组相比，SNP+尼古丁（Nic）处理组大鼠肾上腺髓质中的TH活性以及肾上腺素和去甲肾上腺素水平显著升高。此外，亚甲蓝抑制了TH活性的这种升高。数据表明，在存在Nic的情况下，SNP衍生的NO可能通过鸟苷酸环化酶途径增加TH。