Borman H, Safak T, Ertoy D
Department of Plastic and Reconstructive Surgery, Baskent University, Ankara, Turkey.
Ann Plast Surg. 1998 Aug;41(2):201-4. doi: 10.1097/00000637-199808000-00015.
The 17 patients with fibrosarcoma occurring after radiotherapy for breast carcinoma reported in the literature are the disastrous results of a treatment modality. All the reports concerning the sarcomas share the same feature-aggressive nature with a latent period of 4 years or more. A patient report of fibrosarcoma occurring 2 years after radiotherapy for breast carcinoma with the shortest latent period in the literature is presented and the literature is reviewed. The tumor was localized within an irradiated area and there was a clear histological distinction between the previous and current tumors. The tumor was found to encase the axillary artery and the brachial plexus. For a curative resection, a forequarter amputation was performed and the defect was closed by means of a posterior arm flap. Despite the aggressiveness of the tumors the patient had no distant metastases 1 year after the diagnosis of fibrosarcoma.
文献报道的17例乳腺癌放疗后发生纤维肉瘤的患者是一种治疗方式的灾难性后果。所有关于这些肉瘤的报告都有相同的特征——侵袭性强，潜伏期为4年或更长时间。本文呈现了1例乳腺癌放疗后2年发生纤维肉瘤的患者报告，该潜伏期为文献中最短的，并对文献进行了综述。肿瘤局限于放疗区域内，先前肿瘤与当前肿瘤在组织学上有明显区别。发现肿瘤包绕腋动脉和臂丛神经。为进行根治性切除，实施了上肢截肢术，并用后臂皮瓣封闭缺损。尽管肿瘤具有侵袭性，但在诊断纤维肉瘤1年后患者没有远处转移。
