Hao Jing-Xia, Xu Isabella S, Wiesenfeld-Hallin Zsuzsanna, Xu Xiao-Jun
Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden.
Pain. 1998 Jun;76(3):385-393. doi: 10.1016/S0304-3959(98)00071-2.
We examined the effects of intrathecal nociceptin, the endogenous ligand for the orphan opioid receptor-like receptor, on abnormal pain-related behaviors in rats after carrageenan-induced inflammation and photochemically-induced peripheral nerve or spinal cord ischemic injury. Intrathecal nociceptin dose-dependently alleviated mechanical and cold allodynia-like behavior in the two models of neuropathic pain. The heat hyperalgesia associated with peripheral inflammation was also significantly reduced, although the efficacy of the antihyperalgesic effect of nociceptin in the inflammation model was decreased. Intrathecal nociceptin also induced significant antinociception on the tail-flick test in all three groups of rats. However, the antinociceptive effect of nociceptin was significantly reduced in rats with peripheral nerve injury. These results indicated that spinally administered nociceptin has anti-allodynic and anti-hyperalgesic effects in animal models of tonic or chronic pain of different origins. Peripheral inflammation and nerve injury may induce spinal plasticity which leads to altered potency and efficacy of nociceptin.
我们研究了孤啡肽（一种类阿片受体样受体的内源性配体）鞘内注射对大鼠角叉菜胶诱导的炎症以及光化学诱导的外周神经或脊髓缺血性损伤后异常疼痛相关行为的影响。在两种神经性疼痛模型中，鞘内注射孤啡肽可剂量依赖性地减轻机械性和冷觉异常性疼痛样行为。与外周炎症相关的热痛觉过敏也显著减轻，尽管孤啡肽在炎症模型中的抗痛觉过敏作用效果有所降低。鞘内注射孤啡肽在所有三组大鼠的甩尾试验中也诱导出显著的镇痛作用。然而，在周围神经损伤的大鼠中，孤啡肽的镇痛作用显著降低。这些结果表明，在不同起源的紧张性或慢性疼痛动物模型中，脊髓给予孤啡肽具有抗异常性疼痛和抗痛觉过敏作用。外周炎症和神经损伤可能诱导脊髓可塑性，从而导致孤啡肽的效力和效果发生改变。
