Javier Peñalver F, Somolinos N, Villanueva C, Sánchez J, Monteagudo D, Gallego R
Haematologica. 1998 Jul;83(7):666-7.
We present a 79-year-old man diagnosed with immune thrombocytopenia (ITP), treated with danazol, who died as a result of a spontaneously ruptured spleen. The histopathological diagnosis was splenic peliosis. This patient presents a chronological association between the treatment with danazol and the development of peliosis, which suggests a clear cause-effect relationship. Facing an individual patient with ITP, clinicians should weigh the potential benefits of danazol with the possible development of serious complications, such as hepatic failure or splenic rupture due to peliosis.
我们报告一例79岁男性，诊断为免疫性血小板减少症（ITP），接受达那唑治疗，最终因脾脏自发性破裂死亡。组织病理学诊断为脾紫癜。该患者在接受达那唑治疗与紫癜发生之间存在时间上的关联，提示明确的因果关系。面对ITP个体患者，临床医生应权衡达那唑的潜在益处与可能发生的严重并发症，如因紫癜导致的肝衰竭或脾破裂。
