Iyoda K, Kato M, Nakagawa T, Kakiuchi Y, Sugiyasu Y, Fujii E, Fujimoto K, Michida T, Kaneko A, Hayashi N, Yamamoto K, Kurosawa K, Ikeda M, Masuzawa M
Department of Gastroenterology, Osaka National Hospital, Japan.
J Gastroenterol. 1998 Aug;33(4):588-92. doi: 10.1007/s005350050139.
A 57-year-old man had abnormal hepatic function identified in April 1994. In October 1994, chronic hepatitis C was diagnosed. Based on the findings of a liver biopsy, administration of recombinant interferon (rIFN)-alpha2b was begun. In the 16th week of treatment, the patient experienced headache and fever and developed a markedly decreased, platelet count and hemolytic anemia. He was admitted on May 19, 1995 and thrombotic thrombocytopenic purpura (TTP) was diagnosed. He died on the 3rd hospital day. The causes of TTP have yet to be elucidated, but in this patient the occurrence of TTP appeared to be related to the IFN treatment for chronic hepatitis C.
一名57岁男性于1994年4月被发现肝功能异常。1994年10月，被诊断为慢性丙型肝炎。根据肝脏活检结果，开始给予重组干扰素（rIFN）-α2b治疗。在治疗的第16周，患者出现头痛、发热，并出现血小板计数显著下降和溶血性贫血。他于1995年5月19日入院，被诊断为血栓性血小板减少性紫癜（TTP）。他在住院第3天死亡。TTP的病因尚未阐明，但在该患者中，TTP的发生似乎与慢性丙型肝炎的干扰素治疗有关。
